Chorus

CHORUS –Development of trans esophageal HIFU probe for treating cardiac arythmias

Cardiac arrhythmias are related to a dysfunction of the electrical conduction pathway in the cardiac tissue. When drugs become inefficient, thermal ablation by catheterization is commonly applied. In an attempt to respond to the limitations of these treatments (incomplete lesions, lack of motion compensation and real-time imaging), the CHORUS project aims at developing a transesophageal ultrasonic probe for image-guided thermal ablation. Preliminary in vivo data allowed demonstrating the feasibility of the concept but, before a clinical evaluation, major technological and methodological improvements remains to be done for facilitating the procedure, compensating cardiac motion and improving image guidance for online prediction of lesion assessment.

LabTau Staff

• Cyril Lafon
• Elodie Cao
• Jade Robert
• Francis Bessière

Collaborations

• Hospices Civils de Lyon,
• Vermon (Tours),
• Lyric (Bordeaux),
• LTSI (Rennes)

• Constanciel E, N'Djin WA, Bessière F, Chavrier F, Grinberg D, Vignot A, Chevalier P, Chapelon JY, Lafon C. Design and evaluation of a transesophageal HIFU probe for ultrasound-guided cardiac ablation: simulation of a HIFU mini-maze procedure and preliminary ex vivo trials.
• Bessiere F, N'djin WA, Colas EC, Chavrier F, Greillier P, Chapelon JY, Chevalier P, Lafon C. Ultrasound-Guided Transesophageal High-Intensity Focused Ultrasound Cardiac Ablation in a Beating Heart: A Pilot Feasibility Study in Pigs.
• Kwiecinski W, Bessière F, Colas EC, N'Djin WA, Tanter M, Lafon C, Pernot M. Cardiac shear-wave elastography using a transesophageal transducer: application to the mapping of thermal lesions in ultrasound transesophageal cardiac ablation.
• Greillier P, Ankou B, Bour P, Zorgani A, Abell E, Lacoste R, Bessière F, Pernot M, Catheline S, Quesson B, Chevalier P, Lafon C. Myocardial Thermal Ablation with a Transesophageal High-Intensity Focused Ultrasound Probe: Experiments on Beating Heart Models.