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Place : LabTAU, 151 Cours Albert Thomas, 69003 LYON - Release date : Monday 24 September 2018 - Response deadline : Tuesday 24 September 2019
Blood-brain barrier (BBB) is a specialized structure that regulates molecular passage from the circulatory system into the brain. Focused ultrasound (FUS) combined with intravenously circulating microbubbles can transiently and selectively increase BBB permeability to enable targeted drug delivery to the brain (reviewed in [1]). An overlooked additional application consists in facilitating the entry of brain radiotracers for Positron Emission Tomography (PET), a nuclear imaging technique. In the process of radiotracer development, it is common to reject candidate molecules with high affinity and selectivity because they show poor brain uptake [2]. In the BIORAN team, we have developed a promising radiotracer targeting the serotonin receptor type 6 (5-HT6) [3], which might have crucial implication in obesity and neurodegenerative diseases. However the use of [18F]2FNQ1P in rodent models is hampered by a strong P-gp efflux evidenced by cyclosporine treatment (Fig.1). In collaboration with the Laboratory of Therapeutic Applications of Ultrasound (LabTAU), we aim at testing the ability of focused ultrasound to promote an efficient and reproducible entry of the radiotracer, thus allowing quantitative and longitudinal PET imaging. Practical work will include combined FUS and PET experiments, high-resolution autoradiography, and image analysis.
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Place : LabTAU - Release date : Thursday 3 May 2018 - Response deadline : Friday 3 May 2019
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Place : LabTau (151 Cours Albert Thomas, Lyon 3ème) - Release date : Thursday 25 January 2018 - Response deadline : Friday 25 January 2019
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Place : Laboratoire d’Applications des Ultrasons à la Thérapie - Release date : Wednesday 22 November 2017 - Response deadline : Thursday 31 May 2018
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Place : INSERM, Laboratoire LabTAU, à LYON - Release date : Tuesday 3 October 2017 - Response deadline : Wednesday 31 October 2018
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Place : INSERM, Laboratoire LabTAU, à LYON - Release date : Tuesday 3 October 2017 - Response deadline : Wednesday 31 October 2018
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Place : INSERM, Laboratoire LabTAU, à LYON - Release date : Tuesday 3 October 2017 - Response deadline : Wednesday 31 October 2018
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