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Last updated 7 March 2019

Place : LabTAU, Inserm U1032, 151 Cours Albert Thomas 69003 Lyon / CREATIS - Site INSA, 7 avenue Jean Capelle 69621 Villeurbanne - Release date : Thursday 7 March 2019 - Response deadline : Friday 31 May 2019
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Place : LabTAU, Inserm U1032, 151 Cours Albert Thomas 69003 Lyon - Release date : Wednesday 30 January 2019 - Response deadline : Thursday 30 January 2020
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Place : LabTAU, 151 Cours Albert Thomas, 69003 LYON - Release date : Wednesday 7 November 2018 - Response deadline : Thursday 7 November 2019
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Place : LabTAU, 151 Cours Albert Thomas, 69003 LYON - Release date : Monday 24 September 2018 - Response deadline : Tuesday 24 September 2019
Blood-brain barrier (BBB) is a specialized structure that regulates molecular passage from the circulatory system into the brain. Focused ultrasound (FUS) combined with intravenously circulating microbubbles can transiently and selectively increase BBB permeability to enable targeted drug delivery to the brain (reviewed in [1]). An overlooked additional application consists in facilitating the entry of brain radiotracers for Positron Emission Tomography (PET), a nuclear imaging technique. In the process of radiotracer development, it is common to reject candidate molecules with high affinity and selectivity because they show poor brain uptake [2]. In the BIORAN team, we have developed a promising radiotracer targeting the serotonin receptor type 6 (5-HT6) [3], which might have crucial implication in obesity and neurodegenerative diseases. However the use of [18F]2FNQ1P in rodent models is hampered by a strong P-gp efflux evidenced by cyclosporine treatment (Fig.1). In collaboration with the Laboratory of Therapeutic Applications of Ultrasound (LabTAU), we aim at testing the ability of focused ultrasound to promote an efficient and reproducible entry of the radiotracer, thus allowing quantitative and longitudinal PET imaging. Practical work will include combined FUS and PET experiments, high-resolution autoradiography, and image analysis.
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Place : LabTAU - Release date : Thursday 3 May 2018 - Response deadline : Friday 3 May 2019
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