APACHE
Project Description
Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with a poor 5-year survival rate. This dark prognosis is due to a thick stroma that impedes drug diffusion to tumor cells and promotes tumor growth. Ultrasonic cavitation is a technique that could potentially disrupt this stroma and facilitate the trafficking of chemical agents and biomodulators. Our hypothesis is that a novel cavitation sequence could be designed to disrupt the microenvironment, create entry points into tumor cells, and thus lead to necrosis or apoptosis. Because the pancreas is difficult to access with extracorporeal devices, and endosonography is known for visualizing pancreatic tissue, our goal will be to design an endoscopic cavitation generator capable of reaching any part of the pancreas.
Staff
- Cyril Lafon
- Maxime Lafond
- Magali Perier
- Jacqueline Ngo
- Adrien Rohfritsch
- Marine Simonneau
- Jules Courgenay
Publications
- Laloy-Borgna G, Vovard L, Rohfritsch A, Wang L, Ngo J, Perier M, Drainville A, Prat F, Lafond M, Lafon C, Catheline S. Magnetic microelastography for evaluation of ultrasound-induced softening of pancreatic cancer spheroids. Phys. Rev. Applied 2024; 22, 024024
- Perier M, Wang L, Simonneau M, Ngo-Reymond J, Guillermet-Guibert J, Lafond M, Lafon C. Formation and Characterization of Two Magnetic Three-Dimensional Spheroid Models of Murine Pancreatic Adenocarcinoma. Methods and Protocols, 2025, 8(4), 75.
- Rohfritsch A, Drainville A, Beye B, Renault G, Gannon J, Woodacre J, Chen Y, Barrot L, Lagonnet S, Lafond M, Prat F, Lafon C. Development of an Endoscopic Ultrasound Device for Delivering Microbubble-Mediated Cavitation in the Pancreas : Characterization and Preclinical In-Vivo Results., IEEE T-UFFC 72(10), 1364-1375 (2025).
