Linkedin Labtau 

Education

  • 1980: Engineer graduated from the National Institute of Applied Science (INSA Lyon, France), specialized in Electrical engineering.
  • 1980 – 1982: PhD thesis “Génération et focalisation d’une onde de choc en vue de la destruction transpariétale des calculs rénaux”, U281 INSERM
  • 1982-1985: Postdoc INSERM U281: Study, design and development of an extracorporal lithotritor with echographic imaging.
  • 1984: Recruited as researcher by INSERM

Research:

  • 1986-2000: Research areas: -In-vivo lithotrity applications; Development of new process to ablate automatically the prostate adenoma
  • Since 2000: Cavitation studies; evaluation in Therapy sono-dynamic and sonoporation
    • Study, design and development of regulated cavitation generators
    • Application to the in-vitro cell transfection and molecule internalization
    • Sonodynamical therapy

 

  • 1982: Premier prix forum jeunes chercheurs ITBM-RBM
  • 1986 : Second lauréat Jeune chambre économique de Lyon http://www.jce-lyon.org/backstage/listings/laurier-1986/
  • 2011 : Prix du meilleur abstract et poster aux journées scientifiques du Cancéropôle (CLARA)
  • 2015 : Best Poster Awards ; OMICS International (International Conference on Synthetic Biology)

 

  1. Lafond M, Mestas J-L, Prieur F, Chettab K, Geraci S, Clezardin P, Lafon C. Unseeded inertial cavitationfor enhancing the delivery of chemotherapies: a safety study. Ultrasound in Medicine and Biology 2016; 42:220-31.
  2. Chettab K, Roux S, Mathe D, Cros-Perrial E, Lafond M, Lafon C, Dumontet C, Mestas J-L. Spatial and Temporal Control of Cavitation Allows High In Vitro Transfection Efficiency in the Absence of Transfection Reagents or Contrast Agents. Plos One 2015; 10.
  3. Mestas J-L, Fowler RA, Evjen TJ, Somaglino L, Moussatov A, Ngo J, Chesnais S, Rognvaldsson S, Fossheim SL, Nilssen EA, Lafon C. Therapeutic efficacy of the combination of doxorubicin-loaded liposomes with inertial cavitation generated by confocal ultrasound in AT2 Dunning rat tumour model. Journal of Drug Targeting 2014; 22:688-97.
  4. Sabraoui A, Inserra C, Gilles B, Bera J-C, Mestas J-L. Feedback loop process to control acoustic cavitation. Ultrasonics Sonochemistry 2011; 18:589-94.
  5. Reslan L, Mestas J-L, Herveau S, Bera J-C, Dumontet C. Transfection of cells in suspension by ultrasound cavitation. Journal of Controlled Release 2010; 142:251-58
  6. Villeneuve L, Alberti L, Steghens JP, Lancelin JM, Mestas JL. Assay of hydroxyl radicals generated by focused ultrasound. Ultrasonics Sonochemistry 2009; 16:339-44.
  7. El Maalouf J, Bera J-C, Alberti L, Cathignol D, Mestas J-L. In vitro sonodynamic cytotoxicity in regulated cavitation conditions. Ultrasonics 2009; 49:238-43.
  8. Mestas JL, Lenz P, Cathignol D. Long-lasting stable cavitation. Journal of the Acoustical Society of America 2003; 113:1426-30.
  9. Mestas JL, Cathignol D, Chavrier F, Devonec M. Motorised resection device for transurethral resection of the prostate: a laboratory evaluation. Medical & Biological Engineering & Computing. 1997 Nov;35(6):570-4
  10. Broyer P, Cathignol D, Theillere Y, Mestas JL. High-efficiency shock-wave generator for extracorporeal lithotripsy. Medical & Biological Engineering & Computing 1996; 34:321-28.