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David Melodelima was awarded a PhD degree in Biomedical Engineering in 2004 from the Lyon 1 university for his work in the treatment of esophageal cancers using an intraluminal MR-guided High Intensity Focused Ultrasound (HIFU) device. He then carried out postdoctoral work in radiation force ultrasound elastography at Royal Marsden NHS Trust, Institute for Cancer Research, Sutton, UK. Dr. Melodelima was recruited by the French institute of Health and medical research (INSERM) in 2005 as a research scientist.  He is now senior scientist in the LabTAU (Laboratory of Therapeutic Applications of Ultrasound of INSERM). He is the head of the team “High-Intensity Ultrasound Surgery” of the laboratory. He has a teaching activity in the University Claude Bernard of Lyon and school of engineer Phelma Grenoble. His research covers the entire range of investigation from the bench to the bedside. His main interests deals with therapeutic applications of ultrasound as well as drug delivery using low intensity ultrasound and new method of ultrasound elastography for guiding HIFU treatments. Designing new clinical prototype devices, developing methods of treating difficult regions and studying the biophysics involved in the treatments compliment his theoretical work. He maintains several close clinical and industrial collaborations allowing clinical trials and industrialization of his researches.

David Melodelima received the Christiane Bernardin prize in 2010. He is associate editor for Scientific Reports and Deputy Editor-in-Chief of Innovation and Research in BioMedical Engineering. David Melodelima was a member of the Specialized Scientific Committees (CSS8) of INSERM (2012-2016).

Five main publications :

Dupré A., Melodelima D., Pflieger H., Chen Y., Vincenot J., Kocot A., Langonnet S., Rivoire M. Thermal Ablation of the Pancreas with Intra-Operative High-Intensity Focused Ultrasound (HIFU): Safety and Efficacy in a Porcine Model. Pancreas 2017;46(2):219-224.

Tardoski S., Ngo J., Gineyts E., Roux J.P., Clézardin P., Melodelima D. Low-intensity continuous ultrasound triggers effective bisphosphonate anticancer activity in breast cancer. Scientific Reports 2015;18(5):16354.

Dupré A., Melodelima D., Pérol D., Chen Y., Vincenot J., Chapelon J.Y., Rivoire M. First clinical experience of intra-operative high intensity focused ultrasound in patients with colorectal liver metastases: a phase I-IIa study. Plos One. 2015;10(2):e0118212.

Caloone J., Huissoud C., Vincenot J., Kocot A., Dehay C., Chapelon J.Y., Rudigoz C., Melodelima D. High-Intensity Focused Ultrasound applied to the placental unit using a toroidal-shaped transducer: a preliminary ex-vivo study. Ultrasound in Obstetrics and Gynecology, 2015;45(3):313-319.

Melodelima D., N’Djin A., Parmentier H., Chesnais S., Rivoire M., Chapelon J.Y. Ultrasound surgery with a toric transducer allows the treatment of large volumes over short periods of time, Applied Physics Letters, 2007;91(19):193901.