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Education

Dr Inserra’s area of research is the mechanical behavior of micro-sized inhomogeneity in complex media. He received his PhD degree in Acoustics from the Le Mans University in 2007 in the field of nonlinear acoustics and was awarded by the RWB Stephens Prize at the International Congress of Ultrasonics for his pioneer work on nonlinear acoustics in granular media (2007). After a postdoctoral fellowship in Kyoto University, Japan, under a JSPS program (2007-2008) in nonlinear acoustics of inhomogeneous media, he came back to France in Bordeaux University (Laboratoire de Mécanique Physique) as a postdoctoral research to perform theoretical studies on substrate-cell adhesion properties probed by gigahertz acoustics. He is currently Associate Professor at the University of Lyon, in the Mechanical Engineering Department, and leader of the “Coupling and Control” group of the LabTAU U1032.

Research

Dr Inserra is working on experimental methods to investigate the interaction mechanisms between ultrasound and surrounding biological cell or tissues, amongst others: (i) the control of cavitation activity at the scale of a unique bubble to a collectively interacting bubble cloud, (ii) the acoustic microstreaming induced by oscillating microbubbles exhibiting shape mode oscillations and (iii) the cellular and tissue response to ultrasound and cavitation stimuli in order to determine underlying effects responsible for cell sonoporation. He recently developed experimental techniques for the control of stable and inertial cavitation activity in bubbly media and its implementation for the controlled sonoporation of suspended or adherent cells. This project was conducted through an international collaboration with Taiwanese research teams (ANR-NSC grant SonInCaRe) and French research teams on the physical behavior of free air bubbles in the vicinity of wall or cells monolayer. He also investigates the interaction of bubbles with BBB-mimicking adherent cells in the context of blood-brain carrier opening by ultrasound (ANR-MOST grant CARIBBBOU). His recent researches projects are dealing with the experimental study of time-resolved bubble dynamics of single-bubble nucleated by laser exhibiting nonspherical bubble oscillations, and the evidence of nonlinear coupling between volumic and nonspherical oscillations of microbubbles.

  • 2014: PEDR and PES from the French Ministry of Education and Research

  • 2007: R.W.B. Stephens Prize at the International Congress of Ultrasonics (Vienna, Austria)
  • Co-author of 29 articles in peer-reviewed journals, 32 conferences proceedings, 102 collected citations, h-index 7.
  • Communication in Forum Acusticum 2020: Fauconnier et al. Proceeding

Selection of 10 publications in peer-reviewed journals

  • [1] Surface modes with controlled axisymmetry triggered by bubble coalescence in a high-amplitude acoustkc field. S Cleve, M Guedra, C Inserra, C Mauger, P Blanc-Benon, Physical Review E, 98: 033115, 2018.
  • [2] Focused shockwave induced blood-brain barrier opening and transfection. CH Tsai, KT Chen, YX Lin, YC Li, WS Chen , C Inserra, HL Liu, Scientific Reports, 8: 2218, 2018.
  • [3] Ultrafast monitoring and control of subharmonic emissions of an unseeded bubble cloud during pulse sonication. C Cornu, M Guedra, JC Bera, WS Chen, HL Liu, C Inserra, Ultrasonics Sonochemistry, 42: 697-703, 2018.
  • [4] Dynamics of nonshperical bubble oscillations above instability threshold. M Guedra, S Cleve, C Mauger, P Blanc-Benon, C Inserra, Physical Review E, 96: 063104, 2017.
  • [5] A derivation of the stable cavitation threshold accounting for bubble-bubble interactions. M Guedra, C Cornu, C Inserra, Ultrasonics Sonochemistry, 38: 168-173, 2017.
  • [6] Experimental evidence of nonlinear interactions between spherical and nonspherical oscillations of microbubbles. M Guedra, C Inserra, C Mauger, B Gilles, Physical Review E, 94: 053115, 2016.
  • [7] Sonoporation of adherent cells in regulated ultrasound cavitation. P. Muleki Seya, M. Fouqueray, J. Ngo, A. Poizat, C. Inserra, J.C. Bera, Ultrasound in Medicine and Biology, 41(4): 1008-1019, 2015.
  • [8] Orbital trajectory of an acoustic bubble in a cylindrical resonator. C Desjouy, P Labelle, B Gilles, JC Bera, C Inserra. Physical Review E, 88, 033006, 2013.
  • [9] Control of inertial acoustic cavitation in pulsed sonication using a real-time feedback loop system. C Desjouy, A Poizat, B Gilles, C Inserra, JC Bera. Journal of the Acoustical Society of America, 134 (2), 1640-1646, 2013.
  • [10] Characterization of granular compaction. by nonlinear acoustic resonance method. C Inserra, V Tournat, VE Gusev and B Castagnede. Applied Physics Letters, 92: 191916, 2008.