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MESTAS Jean-Louis
INSERM Researcher
phone :+33 (0)472681944  




1986-2000: Research areas: -In-vivo lithotrity applications; Development of new process to ablate automatically the prostate adenoma

Since 2000: Cavitation studies; evaluation in Therapy sono-dynamic and sonoporation

  • Study, design and development of a regulated cavitation generator
  • Application to the in-vitro cell transfectioin
  • Sonodynamical therapy






1980: Engineer graduated from the National Institute of Applied Science (INSA Lyon, France), specialized in Electrical engineering.

1980 – 1982: PhD thesis “Génération et focalisation d’une onde de choc en vue de la destruction transpariétale des calculs rénaux”, U281 INSERM

1982-1985: INSERM U281: Study, design and developmentof an extracorporal lithotritor with echographic imaging.

1984: Recruited as researcher by INSERM



1. Reslan L, Mestas JL, Herveau S, Béra JC, Dumontet C. “Transfection of cells in suspension by ultrasound cavitation”, J Control Release. 2010 Mar 3;142(2):251-8

2. Villeneuve L, Alberti L, Steghens JP, Lancelin JM, Mestas JL. “Assay of hydroxyl radicals generated by focused ultrasound”, Ultrason Sonochem. 2009 Mar;16(3):339-44

3. El Maalouf J, Béra JC, Alberti L, Cathignol D, Mestas JL. “In vitro sonodynamic cytotoxicity in regulated cavitation conditions”, Ultrasonics. 2009 Feb;49(2):238-43


4. Mestas JL, Lenz P, Cathignol D. “Determination of the acoustic pressure at and the reflection coefficient of a target through measurements of the absorbed power and the emitter voltage”, IEEE Trans Ultrason Ferroelectr Freq Control. 2004 Jan;51(1):109-13.

5. Mestas JL, Lenz P, Cathignol D. “Long-lasting stable cavitation”, J Acoust Soc Am. 2003 Mar;113(3):1426-30.