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INSERRA Claude

Associate Professor in section 60

phone : +33 (0)472681928

 

Research

 

Graduated in Acoustics, my research projects mainly concern nonlinear phenomena in acoustics, like:

- Parametric excitation, harmonic generation and nonlinear resonances to assess hysteretic properties of complex materials (PhD in Le Mans University)

- Bubble dynamics

- Cavitation control

- Nonlinear dynamics of cavitation bubble under bifrequency acoustic perturbation

- Study of bubble-cells interaction in an acoustic field

- Sonoporation (opening and closure of transient pores on cells by ultrasound) process

 

 Projects/Fundings

 

 

ANR-MOST Caribbbou, 2016-2019. France-Taiwan project. Project coordinator.

ANR JCJC ULysSe (Ass. Pr. Bruno Gilles), 2012-2015. Task Leader.

ANR-NSC TecSan SonInCaRe, 2011-2014. France-Taiwan project, Task leader.

 

Education

Since 2009: Associate Professor at the University Claude Bernard Lyon 1.

- Teachings in Solid Mechanics, Numerical Methods, Vibrations and Acoustics at the UFR de Mécanique (UCBL).

- Research works on cavitation phenomenon and sonoporation for therapeutic applications, at the Laboratory of “Applications des Ultrasons à la Thérapie”, INSERM UMR_S1032.

2009: CNRS Postdoctoral fellow at the Laboratory of Mechanics and Physics (LMP, UMR CNRS 5469), Bordeaux University (Bordeaux, France), research project on “Theoretical analysis of capillary waves at the fluid/solid interface in the aim of the biological cell adhesion measurement by picoseconds acoustics”.

2008 – 2009: JSPS Postdoctoral fellow at the Laboratory of Design for Functional Systems, Kyoto University (Kyoto, France), research project on “Linear and nonlinear ultrasonic evaluation of thermally-damaged rocks and granites”.

2004 – 2007: PhD thesis: “Characterization of granular media compaction by linear and nonlinear acoustic methods”, Laboratory of Acoustics of the University of Le Mans (LAUM), UMR CNRS 6613.

2004: Postgraduate degree in applied acoustics, University of Le Mans (Le Mans, France)

2000 - 2003: Engineer graduated from the National School of Engineering of Le Mans (ENSIM), University of Le Mans (France), specialized in Acoustics and Vibrations

 

Awards

R.W.B. Stephens Prize for the best Young Scientist, ICU Vienna, 2007

 

Publications

(2015) Muleki Seya P, Desjouy C, Bera JC, Inserra C. Hysteresis of inertial cavitation activity induced by fluctuating bubble size distribution. Ultrasonics Sonochemistry, 27:262-267.

(2015) Der Loughian C, Muleki Seya P, Pirat C, Inserra C, Bera JC, Rieu JP. Jumping acoustic bubbles on lipid bilayers. Soft Matter, 11: 3460-3469.

(2015) Desjouy C, Fouqueray M, Muleki Seya P, Lo CW, Lee JL, Chen WS, Bera JC, Inserra C. Counterbalancing the use of ultrasound contrast agents by a regulated-cavitation system. Ultrasonics Sonochemistry, 26:163-168.

(2015) Muleki Seya P, Fouqueray M, Ngo J, Poizat A, Inserra C, Bera JC. Sonoporation of adherent cells in regulated ultrasound cavitation. Ultrasound in Medicine and Biology, 41(4):1008-1019.

(2014) Inserra C, Labelle P, Der Loughian C, Lee JL, Fouqueray M, Ngo J, Poizat A, Desjouy C, Munteanu B, Lo CW, Vanbelle C, Rieu JP, Chen WS, Bera JC. Monitoring and control of inertial cavitation activity for enhancing ultrasound transfection: the SonInCaRe project. IRBM, 35(2): 94-99.

(2014) Lee JL, Lo CW, Inserra C, Bera JC, Chen WS. Ultrasound enhanced PEI-mediated gene delivery through increasing the intracellular calcium level and PKC-δ protein expression. Pharmaceutical Research, 31(9): 2354-2366.

(2014) Lo CW, Desjouy C, Chen SR, Jee JL, Inserra C, Bera JC, Chen WS. Stabilizing in-vitro ultrasound-mediated gene transfection by regulating cavitation. Ultrason. Sonochem., 21(2): 833-839.

(2013) Desjouy C, Labelle P, Gilles B, Bera JC, Inserra C. Orbital trajectory of an acoustic bubble in a cylindrical resonator. Phys. Rev. E, 88, 033006.

(2013) Inserra C, Biwa S, Chen Y. Influence of thermal damage on linear and nonlinear acoustic properties of granite. Int. J. Rock. Mech. Min. Sci., 62, 96-104.

(2013) Desjouy C, Poizat A, Gilles B, Inserra C, Bera JC. Control of inertial acoustic cavitation in pulsed sonication using a real-time feedback loop system. J. Acoust. Soc. Am., 134 (2), 1640-1646.

(2013) Desjouy C, Labelle P, Billes B, Bera JC, Inserra C. Acoustic bubble behavior in a standing wave field. J. Acoust. Soc. Am., 133 (5):3277.

(2011) Sabraoui A, Inserra C, Bera J.C and Mestas J.L. Feedback loop system to control acoustic cavitation.Ultrason. Sonochem., 18(2): 589-594.

(2011) Biwa S, Nagae K, Inserra C and Matsumoto E. Nonlinear propagation of amplitude-modulated ultrasonic wave in composite material. Key Engineering Materials, 452-453: 757-760.

(2010) Biwa S, Kishiwada S, Inserra C and Matsumoto E. Modeling of flexural wave propagation in a plate with contacting interfaces. J. Solid Mech. Mater. Eng., 4(8): 1186-1197.

(2009) Kishiwada S, Biwa S, Inserra C and Matsumoto E. Nonlinear ultrasonic characterization of lamb wave in a plate with contacting interfaces. ICCAS-SICE 2009-ICROS-SICE International Joint Conference 2009, Proceedings,5335086, pp.2368-72.

(2009) Inserra C, Biwa S and Chen, Y. Nonlinear ultrasonic characterization of thermally-damaged Westerly granite.Jap. Jour. Appl. Phys., 48:07GD03-1.

(2008) Tournat V, Inserra C, Gusev V.E and Castagnede, B. Non-cascade frequency-mixing processes for elastic waves in unconsolidated granular materials. Ultrasonics, 48(6-7): 492-497.

(2008) Inserra C, Tournat V, Gusev V.E and Castagnede, B. Characterization of granular compaction. by nonlinear acoustic resonance method. Appl. Phys. Lett., 92 :191916.

(2007) Inserra C, Tournat V and Gusev V.E. A method of controlling wave propagation in initially spatially periodic media. Europhys. Lett., 78(4) :44001.