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 BERA Jean-Christophe

Professor at EPUL Section 60

phone :+33 (0)472681940

email: jean-christophe.bera [at] inserm.fr

Coordinator of the Master of Science in Acoustics (http://master-acoustics.ec-lyon.fr)

 

Research

 

Research on control of ultrasound cavitation, particularly on:

- inertial cavitation generation by reduced ultrasound power: applications to ultrasound thrombolysis, transfection.

- acoustic regulation of ultrasound cavitation for cell sonoporation: in vitro applications to  sonodynamic

destruction and transfection;

- ultrasound effects on living cells, in particular stimulation of bone turn-over.


 

 

 

Education

1990: Engineer of Ecole Centrale de Lyon, specialized in Mechanics.

1990: Postgraduate Degree in Acoustics.

1993: PhD of Ecole Centrale de Lyon, thesis on distortion product emissions (non-linear phenomenon linked to inner-ear selectivity mechanisms), in collaboration with Laboratoire d’Exploration Fonctionnelle Auditive (Hôpital E. Herriot, Lyon).

1994: Assistant lecturer (ATER) and contract research engineer at Ecole Centrale de Lyon

1995-2003: Assistant professor (Institut Universitaire de Technologie of Lyon, Department of Industrial Engineering and Maintenance).

Research on acoustic control in Lab of “Mécanique des Fluides et d’Acoustique” (LMFA), about:

-          audition in noise for hearing-impaired,

-          active control for noise reduction,

-          flow control by acoustic microjets, applied to flow vectoring and to drag or noise reduction.

2002: Habilitation à Diriger des Recherches of University Lyon 1, on Active Control in Mechanics.

Since 2004: Professor (ISTIL-EPULyon, engineering school of University Lyon 1, Departments of Mechanics and Biomedical Engineering).

Publications

(2013) Lo CW, Desjouy C, Chen SR, Lee JL, Inserra C, Bera JC, Chen WS. Stabilizing in-vitro ultrasound-mediated gene transfection by regulating cavitation, accepted for publication in Ultrasonics Sonochemistry.

(2013) Desjouy C, Labelle P, Gilles B, Bera JC, Inserra C. Orbital trajectory of an acoustic bubble in a cylindrical resonator. Physical Review E, 88, 033006.

(2013) Gleizal A, Lavandier B, Bera JC, Paris M, Rivoire M, Gourmet R, Fromental R, Langonnet S, Chesnay S. Influence du design implantaire sur l'ostéointégration. DTSC magazine, 1.

(2013) Desjouy C, Poizat A, Gilles B, Inserra C, Bera JC. Control of inertial acoustic cavitation in pulsed sonication using a real-time feedback loop system. J. Acoust. Soc. Am., 134 (2), 1640-1646.

(2013) Ben Chiekh M, Ferchichi M, Michard M, Guellouz MS, Bera JC. Synthetic jet actuation strategies for momentumless trailing edge wake. Journal of Wind Engineering and Industrial Aerodynamics, 113, 59-70.

(2012) Dhahbi M, Ben Chiekh M, Gilles B, Bera JC, Jemni A. Numerical simulation of particle dynamics in a poststenotic blood vessel region within the scope of extracorporeal ultrasound stenosis treatment. Med. Eng. Phys., 34 (7), 982-989.

(2012) Ben Chiekh M, Ferchichi M, Bera JC. Aerodynamic flow vectoring of a wake using asymmetric synthetic jet actuation. Experiments in Fluid, 53 (6), 1797-1813.

(2012) Gaudrain E, Grimault N, Healy E, Bera JC. The relationship between concurrent speech segregation, pitch-based straming of vowel sequences, and frequency selectivity. Acta Acustica united with Acustica, 98 (2), 317-327.

(2012) Ben Chiekh M, Michard M, Guellouz MS, Bera JC. POD analysis of momentumless trailing edge wake  using synthetic jet actuation. Experimental Thermal and Fluid Science, 46, 89-102.

(2011) Ben Chiekh M, Ferchichi M, Bera JC. Modified flapping jet for increased jet spreading using synthetic jets. International Journal of Heat and Fluid Flow, 32 (5), 865-875.

(2011) Sabraoui A, Inserra C, Gilles B, Bera JC, Mestas JL. Feedback loop process to control acoustic cavitation. Ultrason. Sonochem., 18 (2), 589-594.

(2011) Saletes I, Gilles B, Bera JC. Promoting inertial cavitation by nonlinear frequency mixing in a bifrequency focused ultrasound beam. Ultrasonics, 51 (1), 94-101.

(2011) Gleizal A, Lavandier B, Paris M, Bera JC. Contribution of low-intensity pulsed ultrasound to bone regeneration. Rev. Stomatol. Chir. Maxillofac., 112 (4), 233-239.

(2010) Reslan L, Mestas JL, Herveau S, Bera JC, Dumontet C. Transfection of cells in suspension by ultrasound cavitation. Journal of Controlled Release, 142 (2), 251-258.

(2010) Gleizal A, Ferreira S, Lavandier B, Simon B, Beziat JL, Bera JC. The impact of low-intensity pulsed ultrasound on mouse skull bone osteoblast cultures. Rev. Stomatol. Chir. Maxillofac., 111 (5-6), 280-285.

(2009) El Maalouf J, Béra JC, Alberti L, Cathignol D, Mestas JL. In vitro sonodynamic cytotoxicity in regulated cavitation conditions, Ultrasonics 49(2), 238-43.

(2009) Lavandier B, Gleizal A, Béra JC. Experimental assessment of calvarial bone defect re-ossification stimulation using low-intensity pulsed ultrasound, Ultrasound Med Biol 35(4), 585-94.

(2008) Gaudrain E, Grimault N, Healy E, Béra JC. Streaming of vowel sequences based on fundamental frequency in a cochlear implant simulation, J Acoust Soc Am 124(5), 3076-87.

(2008) Castelain T, Sunyach M, Juvé, D, Béra JC. Jet-noise reduction by impinging microjets: an acoustic investigation testing microjet parameters, AIAA Journal 46(5), 1081-1087.