Equipment and Platforms

Equipment

LabTAU is home to state-of-the-art calibration and characterization facilities for therapeutic and diagnostic ultrasound. The laboratory also homes specific research open platforms dedicated to the development of new imaging and therapeutic ultrasound strategies.

Ultrasound pressure fields hydrophone measurement motorized platforms

  • 2 custom benches, 1 Precision Acoustic bench
  • Ultrasound hydrophones (piezoelectric, optical)
  • Hydrophone calibration bench (custom)
  • Degassed water platforms (customs)

Custom

UMS, Precison Acoustic

FOPH 2000 (RP Acoustics) and PAFOH26 (Precision Acoustics)

Hydrophone calibration bench (custom)

Ultrasound radiation force balances

RFB-2000 (Onda)

Optical characterization platforms

  • Laser interferometer benches (e.g. vibrometry measurements transducer/biological tissue vibration modes)
  • Ultrafast optical imaging (e.g. bubble cavitation dynamic)
  • Spectroscopy
  • Fluorescence microscopy
  • Long working distance microscopy (e.g. microelectronic, CMUT characterization)

Laser interferometer (SH-140, Thales)

Laser interferometer (MGL-F-532-2W, CNI)

Ultrafast camera (Phantom, Vision Research)

Spectro-fluorometer (Fluoro-Max4, Horiba)

Fluorescence microcope (Eclipse Ti-S, Nikon)

Long working distance microscope (CX3-2300S-V6, Omano): e.g. Zoom in of a CMUT element

Ultrasound imaging platforms for US therapy guidance and medical diagnosis:

  • 2 research ultrasound scanners BK
  • 1 open research ultrasound scanner Ultrasonix
  • 2 open research ultrasound Verasonics systems for dual-mode ultrasound (512 channels): pulsed ultrasound for imaging (e.g. ultrafast passive elastography) and LEUS therapy, continuous ultrasound for HIFU therapy

Research ultrasound scanners (Hawk 2102 EXL, BK Medical)

Research ultrasound scanner (500 RP, Ultrasonix)

Research dual-mode ultrasound system (Vantage 256, Verasonics): US imaging + HIFU therapy.

The two 256-channels systems can be synchronized to form a single 512-channel system

Biological platform (L2)

  • Microbiological security platform
  • Centrifuge systems

PSM

Centrifuge systems:

5804 R, Eppendorf

Sigma

Animal experiment platforms

  • 2 gas anesthesia platforms

Gas Anesthesia (Tem Sega)

Robotic and Augmented Navigation platforms for US treatment planning:

  • 2 robotic arms
  • 1 optical tracking system
  • 1 magnetic tracking system

Robotic arm (VS-050A3-AV6, DENSO)

Augmented navigation platform including a spatial tracking system (optical: Polaris Spectra, NDI; or magnetic: Aurora, NDI) and a CE certified robotic arm (LBR iiwa, KUKA)

Mechanical and electrical fabrication platforms :

  • Workshop
  • 3D-printing platforms
  • Metallization system

Workshop

3D-printing platforms

Metallization system

(E5100, Bio-Rad)

Labtau Platforms


Cermep platforms

https://www.cermep.fr/ged.php?login=vvv&catagenda=678404593d4722c&pk_org...

The LabTAU regularly uses CERMEP facilities for numerous work requiring heavy imaging equipment, especially (not exclusively) MRI equipment for the development of new MRgHIFUstrategies at the preclinical level. The CERMEP is a medical imaging center, where are conducted experimental and clinical research, located inside the NeuroCardiology Hospital of Lyon.

Primage platform (Neurosciences)

  • 3T MRI scanner (Magnetom Prisma, Siemens) : First french installation in Lyon

Interventional MRI platform (Neurosciences, cardiology, muscular pathologies …):

  • 1.5T MRI scanner (AvantoFit, Siemens)
  • Operative room

Animage platform

  • Animal facilities
  • 7T MRI scanner, small animal (Brucker)
  • Micro PET/CT scanner (Inveon, Siemens)

PET/CT platform

  • Biograph mCT (Siemens)

Radiochemistry platform

  • Biomedical cyclotron (IBA)
  • Radiochemical shielded rooms
  • Automated marker synthesis
  • Analytical Control room (Quality control)

PET/MRI platform: LILI and IHU Cesame (Neurosciences, cancerology, cardiology, muscular pathologies, image sequences developments)

  • PET/MRI scanner (Biograph mMR, Siemens)

MEG platform (Brain)

  • CTF Omega 275

Spectral scanner platform

Spectral scanner with photonic counting (Philips): world first installation in Lyon

 

ICE Surgery Laoboratory - Experimental Surgery Institute

UMR CLB – Inserm LabTau U1032

The ICE surgery laboratory is a transfer research platform: allows researchers to develop and test new surgical techniques on relevant animal models in an adapted and safe operating room before they can be made available for the patients.

Expertise:
Tumor destruction by physical agents
Development of new techniques of tumor destruction (physical and chemical) usable in surgery and interventional radiology.
Development of new models to meet the needs of other teams.

The ICE surgery laboratory is a joint research unit (UMR) created in June 2005 and led by Professor Michel Rivoire.
Its objective is to provide a platform for experimental surgery designed for oncological translational research. It therefore allows the gathering of a labelled INSERM Unit (LabTau U1032, application of ultrasound therapy), a clinical unit of surgical oncology (Center Léon Bérard, Department of Surgery), the Faculty of Medicine Claude Bernard, and industrial partners.
This structure also has a role in the teaching of experimental surgery and in the training of future doctors: Supervision of PhD and Science Masters, Experimental surgery formations, training on specific hardware (CHIP, laparoscopy, endoscopy ...).

The technology platform includes:

  • Two fully equipped surgical blocks with 4 workstations
  • Fully trained and experienced staff with all the regulatory authorizations
  • Recognized clinical expertise (Surgery, Oncology, Radiology ...)
  • Rich research environment (LabTau, Lyric, CRCL, BEC ...)
  • Scientific supervision (Anesthesiology, Biology, Biostatistics, Pathology...)
  • Logistical support (Pharmacy, sterilization ...)
  • Internal registered ethics committee which reviews every project before it is allowed to start.

Its general theme is the destruction of tumour by physical agents and more particularly the development of new techniques for tumour destruction (physical and chemical) to be used in surgery and interventional radiology.

  • To treat more patients in a curative approach,
  • To improve efficiency,
  • To limit invasivity,
  • To limit morbidity.

Several teams are working within the ICE on specific topics directly related to its general theme:

  • Targeting liver tumours
  • Tumour Destruction by HIFU
  • maxillo-facial reconstruction in irradiated area
  • Liver Regeneration and targeted therapyDevelopment of relevant models


The ICE Surgery Laboratory is a platform for translational research: it allows researchers to develop and test new surgical techniques on animal models in suitable and secured surgical block before they can be proposed to patients.